Spinal Cord Injury (SCI)
Reducing secondary injury and driving functional recovery after spinal cord injury.
Spinal cord injury has a prevalence of 40–80 per million. Pre-clinically, GDNF delivered rostral to the lesion significantly increases functional recovery.
After injury, much of the lasting damage comes from a secondary cascade of inflammation, cell death and scarring. GDNF reduces this secondary injury, is neuroprotective and neurorestorative to motor and sensory neurons, promotes axonal sprouting and remyelination, increases blood supply and reduces the size of the spinal cord lesion.
Innervate delivers to the pons, with axonal transport to primary and secondary motor neurons, the cerebellar nuclei and sensory neurons — reaching the networks needed to restore function after injury.
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